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NANO Gets Personal with Cancer Treatments – Technion Israel

 

New drug-delivery capsule may replace injections

 

Choosing proper lipids for your nanoscale drug/siRNA carrier

  • Lecturer(s): Avi Schroder (Technion)
  • Location: TAU
  • Date: Sunday, 15 June 2014

From Chemotherapy To Nano-Robots

תרופות ממוקדות מטרה.

Next Generation: In Vivo Drug Factories

Researchers use UV light to stimulate protein production in nano-sized delivery capsules in mice.

Sabrina Richards for The Scientist, 13/9/2012

Science is one step closer to producing drugs in the right place at the right time in the body, avoiding the collateral damage of untargeted treatments. Researchers led by Daniel Anderson at the Massachusetts Institute of Technology have designed nanoparticles that can be stimulated via UV light to produce proteins on demand in vivo.

Making Drugs Inside the Body

Peter Gwynne for InsideScience.org, 8/9/2012

Researchers have developed a new type of nanoparticle that is capable of synthesizing proteins on demand. The effort marks a first step toward inventing a new method of attacking cancer cells in humans.
The Massachusetts Institute of Technology team has shown that a beam of ultraviolet light can trigger protein production in nanoparticles located in the bodies of laboratory mice.
Introduced into the bodies of cancer patients, the nanoparticles would target tumors. Once there, ultraviolet light beamed at the nanoparticles’ location from outside the body would start the synthesis of protein drugs that would kill the cancer cells.

Dr. Avi Shroeder in a Israeli TV program “Osim Seder” (Hebrew)

2/9/2012

Avi Schroeder talks in popular Israeli TV program “Osim Seder”, expressing his views on perspectives of BioTech potential in Israel. While Israeli hightech companies are world-widely known for their unprecedented success, much should be done for Israeli biotech to become a science epicenter.

Returning Scientists

Alex Doron, Maariv, 29/8/2012

לפני שנתיים וחצי בערב קר ומושלג בבוסטון נאספו יותר מ-200 מדענים ישר-אלים באולם הרצאות במכון הטכנולוגי של מסצ’וסטס (MIT). אורחם היה שר האוצר, ד”ר יובל שטייניץ, שהגיע “להרביץ בהם ציונות”, כפי שהוגדר האירוע במשרדו. מאזיניו היו בעלי תואר שלישי שנרכש בלימודים בישראל ושהו בארה”ב להתמחויות פןסט-דוקטורט. “התרשמתי”, נזכר ד”ר עידו חניאל, “שהשר הופתע מכמות אנשים שבאו לשמוע אותו, ואולי הוא לא היה מודע לממדי הקהילה המדעית הישר-אלית במסצ’וסטס, דוגמה אחת למתרחש בארה”ב”.

A step toward minute factories that produce medicine inside the body

ACS News Service Weekly PressPac: 12/8/2012

Scientists are reporting an advance toward treating disease with minute capsules containing not drugs — but the DNA and other biological machinery for making the drug. In an article in ACS’ journal Nano Letters, they describe engineering micro- and nano-sized capsules that contain the genetically coded instructions, plus the read-out gear and assembly line for protein synthesis that can be switched on with an external signal.

Made to order: Making medicine in the part of the body that needs it may soon be possible

14/7/2012

Devising effective drugs is only half the battle faced by pharmaceutical companies. The other half is delivering them to the place in the body they are needed. Pills and potions are easy to pop, but they must then run the gauntlet of the gastrointestinal tract, with its hostile acids and enzymes. Injections bypass that difficulty, but they are unpleasant for the patient and, if they have to be carried out repeatedly, can be damaging. Skin patches and nasal sprays are alternatives for some medicines. But all these methods share a problem. The drug is generally being given to the entire body, when it is actually wanted in only one, specific place. Some researchers, therefore, are exploring an alternative: building tiny factories that make and release a drug precisely where it is needed.

Ultrasound pill helps the medicine go down

Will Ferguson for NewScientist, 25/6/2012

Daily injections are a painful fact of life for many people with diabetes or cancer. Pills are an easier and more pleasant treatment method but substances like insulin do not penetrate tissue quickly enough to be effective when taken orally. Now a pill that uses ultrasound to speed up drug delivery could remove the need for needles.

Protein Factories: Nanoparticles that synthesize proteins could treat cancer

Anne Trafton for MIT TECHNOLOGY REVIEW, 19/6/2012

Drugs made of protein have shown promise in treating cancer, but they are difficult to deliver because the body usually breaks down proteins quickly.

To get around that obstacle, a team of MIT researchers has developed a new type of nanoparticle that can synthesize proteins on demand. Once these “protein factory” particles reach their targets, the researchers can initiate protein synthesis by shining ultraviolet light on them.

Israeli researcher unveils cancer-fighting robots

Judy Siegel-Itzkovich for Jerusalem Post, 17/5/2011

New experimental technology using “programmable injectable nano-robots” to treat cancer mestastasis was revealed on Monday at a scientific conference by Dr. Avi Schroeder, an Israeli at the Massachusetts Institute of Technology.

The promising tiny robots, just 170 nanometers in diameter, function like minifactories to produce functional proteins that fight cancer when triggered by irradiated light from an swallowable capsule; this is similar to the Israeli Given Imaging capsule for investigating the gastrointestinal system.

Injectable protein nanofactories

Nature research Highlights, 19/4/2012

Tiny injectable particles containing protein ‘factories’ can be remotely activated by ultraviolet light. The technique could ultimately be used for drug delivery.

Koch Institute Image Awards Winners: Gaurav Sahay, Avi Schroeder and Paulina Hill

2011

In this video Dr. Avi Schroeder and other member of the team explain the principles by which….